RESEARCH PAPERS
RESEARCH MATERIAL
Our approach is rooted in continuous learning and transparency. We believe it's important to share the research that informs our hands-on, non-invasive treatment approach.
The studies below explore the causes and impact of soft tissue fibrosis and adhesion — key contributors to chronic pain. While many focus on surgical solutions, we apply these insights to guide our non-surgical care.
Please note: These papers are clinical in nature and may be technical for general readers.
CHRONIC CONDITIONS, DIAGNOSIS & TREATMENT
- Posterior Hip and Buttock Pain: Relation to Deep Gluteal Syndrome | biomedres.us
- Sciatic Nerve Entrapment due to Fibrous Adhesion in the Deep Gluteal Space- Proposed Clinical Diagnostic Criteria and Therapy Using Manual Adhesion Release® | clinmedjournals.org
- Deep gluteal syndrome: anatomy, imaging, and management of sciatic nerve entrapments in the subgluteal space | pubmed.ncbi.nlm.nih.gov
- The Endoscopic Treatment of Sciatic Nerve Entrapment-Deep Gluteal Syndrome | pubmed.ncbi.nlm.nih.gov
- Stretching of roots contributes to the pathophysiology of radiculopathies | pubmed.ncbi.nlm.nih.gov
- Anatomical etiology of “pseudo-sciatica” from superior cluneal nerve entrapment: a laboratory investigation | doi.org
- Anatomical study of superior cluneal nerve entrapment | pubmed.ncbi.nlm.nih.gov
- Association between intermittent low-back pain and superior cluneal nerve entrapment neuropathy | pubmed.ncbi.nlm.nih.gov
- Fibrous adhesive entrapment of lumbosacral nerve roots as a cause of sciatica | pubmed.ncbi.nlm.nih.gov
- Increased Fibrogenic Gene Expression in Multifidus Muscles of Patients With Chronic Versus Acute Lumbar Spine Pathology | pubmed.ncbi.nlm.nih.gov
- Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury | pubmed.ncbi.nlm.nih.gov
- Reduced thoracolumbar fascia shear strain in human chronic low back pain | ncbi.nlm.nih.gov
SHOCKWAVE FOR MUSCULOSKELETAL DISORDERS
- Extracorporeal shockwave therapy in musculoskeletal disorders | josr-online.biomedcentral.com
- Extracorporeal shock wave therapy mechanisms in musculoskeletal regenerative medicine | journal-cot.com
- Radial extracorporeal shockwave promotes subchondral bone stem/progenitor cell selfrenewal by activating YAP/TAZ and facilitates cartilage repair in vivo | stemcellres.biomedcentral.com
- Enhanced Spinal Therapy: Extracorporeal Shock Wave Therapy for the Spine | ncbi.nlm.nih.gov
- Low energy extracorporeal shock wave therapy combined with low tension traction can better reshape the microenvironment in degenerated intervertebral disc regeneration and repair | pubmed.ncbi.nlm.nih.gov
- Biological response of extracorporeal shock wave therapy to tendinopathy in vivo | ncbi.nlm.nih.gov
- Impact of radial extracorporeal shock wave therapy in post-laminectomy epidural fibrosis in a rat model | ncbi.nlm.nih.gov
- Shock wave as biological therapeutic tool: From mechanical stimulation to recovery and healing, through mechanotransduction | pubmed.ncbi.nlm.nih.gov
- The effect of extracorporeal shock wave on joint capsule fibrosis in rats with knee extension contracture: a preliminary study | tandfonline.com
AGEING, DEGENERATION & FIBROSIS/ADHESION
- Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis | science.sciencemag.org
- Structural and Functional Changes in the Coupling of Fascial Tissue, Skeletal Muscle, and Nerves During Aging | ncbi.nlm.nih.gov
- Alterations in quadriceps muscle cellular and molecular properties in adults with moderate knee osteoarthritis | ncbi.nlm.nih.gov
- The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis | ncbi.nlm.nih.gov
- The association of cervical sagittal alignment with adjacent segment degeneration | link.springer.com
- Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases | ncbi.nlm.nih.gov
- Senescent cells: an emerging target for diseases of ageing | ncbi.nlm.nih.gov
- Roles of Articular Cartilage Aging and Chondrocyte Senescence in the Pathogenesis of Osteoarthritis | ncbi.nlm.nih.gov
ADHESION / FIBROSIS DEVELOPMENT
- Pathophysiological Tissue Changes Associated With Repetitive Movement: A Review of the Evidence | ncbi.nlm.nih.gov
- Hypoxia-generated superoxide induces the development of the adhesion phenotype | ncbi.nlm.nih.gov
- Modulation of fibroblast proliferation by oxygen free radicals | pubmed.ncbi.nlm.nih.gov
- Low Oxygen Stimulates Proliferation of Fibroblasts Seeded as Single Cells | doi.org
- Tensile Mechanical Properties of Three-Dimensional Type I Collagen Extracellular Matrices With Varied Microstructure | pubmed.ncbi.nlm.nih.gov